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16.04.2018 Homogenising and drying of APIs

AVA, Herrsching, Germany, recently won an order to supply an HVW-VT 120 vertical conical dryer with spiral mixing unit in pharmaceutical design to Chinoin Zrt, a subsidiary of the French pharmaceutical company Sanofi. Chinoin has plants in Hungary at three main locations: Budapest, Csanyikvölgy and Veresegyház. In mid-2018 the chemical site in Budapest will take delivery of a new system for homogenising and drying of active pharmaceutical ingredients and excipients, the centrepiece of which will be the new AVA mixer-dryer.
Here the active ingredient is sprayed on to the excipient in liquid, dissolved form and then homogenised. After achieving the required distribution of active ingredients and excipients, the carrier liquid is removed by applying vacuum and heating the exterior wall. The dryer is finally discharged by a continuous liner system with integrated weighing cells. Owing to the toxic properties of the active ingredient, the system was designed to achieve containment level OEB 3. After a residue-free emptying, the dryer including liner system is CIP cleaned and dried in preparation for the next batch. AVA, which earlier this year joined forces with BHS-Sonthofen (see last week’s EBS News) will be exhibiting at ACHEMA, Hall 6.0, Stand D19. 
AVA vertical conical dryer with spiral mixing unit

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