A Parsum in-line particle sizing probe from UK-based Malvern Instruments is proving its value as an analytical instrument in granulation research being conducted at Ghent University in Belgium. Professor Thomas De Beer’s Process Analytical Technology (PAT) group at the university are successfully using the instrument for continuous monitoring of granulation processes and to develop effective automated strategies for process control. 
The Process Analytical Technology group is part of the faculty of Pharmaceutical Sciences and focuses on identifying robust and relevant PAT tools. The team researches how these can be applied to improve manufacturing efficiency. Granulation trials have shown that real-time particle size measurements, in combination with other analytical data, support consistent production of granules to a defined specification. 
PAT is playing a key role in achieving the pharmaceutical industry’s stated aims of moving away from batch operation and off-line monitoring towards continuous, integrated processing. For further details of Prof De Beer’s work visit: http://bit.ly/ProfTDBeer . More information about the Parsum probe can be found at: www.malvern.com/velocimetry
 

The Parsum probe, suitable for particles within the 50-6000 microns size range, installed in a fluidised bed granulator
 

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